Micky van de Ven Double Ends The Toffees' Run at Brand New Stadium
Micky van de Ven emerged as the first backline player to score two goals in a Premier League game for Tottenham since Jan Vertonghen in March 2013.
Match summary
The Spurs defender heads home twice in opening period
The home side's defender has equalizer ruled after video check
Senegalese midfielder scores final goal in dying moments
The defeat is Everton's initial at their new ground
The Tottenham defender scored twice as Tottenham extended their unbeaten run in away games in the Premier League and delivered the Toffees their first defeat at Hill Dickinson Stadium.
Everton were unbeaten in their last five matches at their recently opened stadium at Bramley-Moore Dock, having left their historic home behind after 133 years at the conclusion of the previous campaign.
But Spurs captain the Dutchman pounced on two occasions from corners in the opening 45 minutes to place their impressive record at risk, and they were unable to turn it around before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - headed home a third to put the game to bed.
Jake O'Brien believed he had levelled the scores a short while after the defender's first goal, directing a powerful header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, failed to convert a number of opportunities, while the Italian goalkeeper made a succession of fine stops to guarantee the London club went five away games unbeaten in the Premier League.
But the VAR intervened, instructing the match official to check the goal on the screen and the referee ruled that the winger and the attacker were in offside positions and had impeded with the Spurs keeper.
This victory elevates Thomas Frank's side into third place in the Premier League, a handful of points off north London rivals and table-toppers the Gunners.
Everton stay 14th and are six points clear of the drop zone.
Tottenham analysis: Van de Ven excels in role at each end of the field
After a drab weekday display in the European competition against Monaco, where they managed a mere two shots on goal, Frank opted for the French striker up front instead of former Toffees player the Brazilian.
The summer signing was failed to influence the game before being substituted for Richarlison after 60 minutes on the field, but it turns out he wasn't needed in the end.
Defender Van de Ven transformed into an attacking force to be reckoned with.
Tottenham's opening strike came from a cleverly executed corner routine, with Rodrigo Bentancur heading the ball back across the face of goal for an free Van de Ven to score.
And the captain - stepping up as captain in the Argentine's absence - added his next goal in first-half stoppage time as he rose above the England keeper to nod in.
Van de Ven was equally outstanding in defensive duties, combining well with Kevin Danso as the pair handled superbly with the 34 crosses sent their way by Everton.
Toffees breakdown: Toffees missing finishing touch
Everton's recent stadium had been a happy hunting ground, but it appears the freshness may have faded somewhat and fans flocked to the gates after the midfielder's third for Tottenham.
The end in Everton's winning streak at home will not be a massive concern for David Moyes, but their attacking woes are.
The forward and the other striker - the Everton's two established strikers - had scored only one league goal combined before the weekend's outing.
And they were unable to add to that miserable tally on a damp and dreary night on Merseyside.
Beto's performance was summed up when he chose to bicycle-kick a clear chance from near the goal, despite having space and time to readjust for a more conventional shot that would have tested Vicario.
The substitute, too, was unable to influence the game after coming on for the starter in the second half.
It was not for a lack of opportunity. The majority of the home side's offensive moves came through the winger and Ndiaye, who relentlessly delivered threatening crosses into the Tottenham box.
What next for these two sides?
The Toffees: Moyes' men head to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: The London club go to St James' Park on late October for their fourth-round Carabao Cup tie against the Magpies.